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Editor-in-Chief Melissa Norton, MD
Biology Editor Penelope Webb, PhD
In-house Editor Matt Hodgkinson
Welcome to BMC Bioinformatics published by BioMed Central
BMC Bioinformatics
is an open access journal publishing original peer-reviewed research
articles in all aspects of computational methods used in the analysis
and annotation of sequences and structures, as well as all other areas
of computational biology. BMC Bioinformatics (ISSN 1471-2105) is
indexed/tracked/covered by PubMed, MEDLINE, BIOSIS, CAS, Scopus,
EMBASE, Thomson Scientific (ISI) and Google Scholar.
Research highlights
BMC Bioinformatics 2007, 8 :254
Progressive multiple sequence alignments using
exact dynamic programming to achieve three-way alignment avoids the gap
errors that are inevitable with pairwise alignments.
BMC Bioinformatics 2007, 8 :252
The Universal Similarity Metric, a
compression-based method for assessing biological sequence similarity,
is robust, flexible, scalable, competitive with existing techniques and
- owing to its foundations in Kolmogorov Complexity - alignment free.
BMC Bioinformatics 2007, 8 :225
As two rare amino acids are stop codon-encoded, a
23rd undiscovered amino acid might also be, but a systematic search for
'readthrough proteins’ in prokaryotes showed no trace of an additional stop codon-encoded amino acid.
BMC Bioinformatics 2007, 8 :198
The Automated Clone Evaluation (ACE) system, a
web-based plasmid sequence verification platform, replaces the
laborious manual evaluation of thousands of protein expression clones
with an automatic check of sequences against user-defined criteria.
BMC Bioinformatics 2007, 8 :138
Transcription factor binding site maps are a
powerful way to reveal conserved regulatory elements within both
promoters and 3' untranslated regions that may be missed by sequence
alignments when sequence conservation is lacking.
Latest supplements published in BMC Bioinformatics
Volume 8 Suppl 5
Research
Venice, Italy. 2-5 April 2006
[contents ]
Volume 8 Suppl 4
Proceedings
La Jolla, CA, USA. 30 August – 1 September 2006
[contents ]
Latest articles published in BMC Bioinformatics
more info ]
Research article
Gene analogue finder: a GRID solution for finding functionally analogous gene products Angelica Tulipano, Giacinto Donvito, Flavio Licciulli, Giorgio Maggi, Andreas Gisel BMC Bioinformatics 2007, 8 :329 (3 September 2007) [Abstract ] [Provisional PDF ]
Software
GeneSrF and varSelRF: a web-based tool and R package for gene selection and classification using random forest Ramon Diaz-Uriarte BMC Bioinformatics 2007, 8 :328 (3 September 2007) [Abstract ] [Provisional PDF ]
Software
ASMPKS: an analysis system for modular polyketide synthases Hongseok Tae, Eun-Bae Kong, Kiejung Park BMC Bioinformatics 2007, 8 :327 (3 September 2007) [Abstract ] [Provisional PDF ]
Research article
Stratification bias in low signal microarray studies Brian J Parker, Simon Gunter, Justin Bedo BMC Bioinformatics 2007, 8 :326 (2 September 2007) [Abstract ] [Provisional PDF ]
Research article
BIOSMILE: A semantic role labeling system for
biomedical verbs using a maximum-entropy model
with automatically generated template features
Richard Tzong-Han Tsai,
Wen-Chi Chou, Ying-Shan Su, Yu-Chun Lin, Cheng-Lung Sung, Hong-Jie Dai,
Irene Tzu-Hsuan Yeh, Wei Ku, Ting-Yi Sung, Wen-Lian Hsu BMC Bioinformatics 2007, 8 :325 (1 September 2007) [Abstract ] [Provisional PDF ]
Research article
Mining and state-space based modeling and verification of sub-networks from large biomolecular networks Xiaohua Hu, Fang-Xiang Wu BMC Bioinformatics 2007, 8 :324 (31 August 2007) [Abstract ] [Provisional PDF ]
Research article
Optimization of filtering criterion for SEQUEST database searching to improve proteome coverage in shotgun proteomics Xinning Jiang, Xiaogang Jiang, Guanghui Han, Mingliang Ye, Hanfa Zou BMC Bioinformatics 2007, 8 :323 (31 August 2007) [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research article
Statistical validation of megavariate effects in ASCA Daniel J Vis, Johan A Westerhuis, Age K Smilde, Jan van der Greef BMC Bioinformatics 2007, 8 :322 (30 August 2007) [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research article
Automatic generation of 3D motifs for classification of protein binding sites Jean-Christophe Nebel, Pawel Herzyk, David R Gilbert BMC Bioinformatics 2007, 8 :321 (30 August 2007) [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Software
Apollo2Go: a web service adapter for the Apollo genome viewer to enable distributed genome annotation Kathrin Klee, Rebecca Ernst, Manuel Spannagl, Klaus F. X. Mayer BMC Bioinformatics 2007, 8 :320 (30 August 2007) [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
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Research article
Global analysis of host response to induction of a latent bacteriophage Robin E Osterhout, Israel A Figueroa, Jay D Keasling, Adam P Arkin BMC Microbiology 2007, 7 :82 (31 August 2007) [Abstract ] [Provisional PDF ]
Research article
Epstein-Barr virus latency switch in human B-cells: a physico-chemical model Maria Werner, Ingemar Ernberg, JieZhi Zou, Jenny Almqvist, Erik Aurell BMC Systems Biology 2007, 1 :40 (31 August 2007) [Abstract ] [Provisional PDF ]
Methodology article
Modeling gene expression regulatory networks with the sparse vector autoregressive model Andre Fujita, Joao R Sato, Humberto M Garay-Malpartida, Rui Yamaguchi, Satoru Miyano, Mari C Sogayar, Carlos E Ferreira BMC Systems Biology 2007, 1 :39 (30 August 2007) [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research
Developing
combinatorial multi-component therapies (CMCT) of drugs that are more
specific and have fewer side effects than traditional one drug therapies Larry S Liebovitch, Nicholas Tsinoremas, Abhijit Pandya Nonlinear Biomedical Physics 2007, 1 :11 (30 August 2007) [Abstract ] [Provisional PDF ]
Research
Reconstruction of cellular variability from spatiotemporal patterns of Dictyostelium discoideum Christiane Hilgardt, Stefan C Mueller, Marc T Huett Nonlinear Biomedical Physics 2007, 1 :10 (30 August 2007) [Abstract ] [Provisional PDF ]
Method
Model-based Analysis of 2-Color Arrays (MA2C) Jun S Song, W Evan Johnson, Xiaopeng Zhu, Xinmin Zhang, Wei Li, Arjun K Manrai, Jun S Liu, Runsheng Chen, X Shirley Liu Genome Biology 2007, 8 :R178 (29 August 2007) [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research
Distribution patterns of small-molecule ligands in the protein universe and implications for origin of life and drug discovery Hong-Fang Ji, De-Xin Kong, Liang Shen, Ling-Ling Chen, Bin-Guang Ma, Hong-Yu Zhang Genome Biology 2007, 8 :R176 (29 August 2007) [Abstract ] [Full text ] [PDF ] [PubMed ] [Related articles ]
Research article
Spectrum of disease-causing mutations in protein secondary structures Sofia Khan, Mauno Vihinen BMC Structural Biology 2007, 7 :56 (29 August 2007) [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research article
Visualizing
differences in phylogenetic information content of alignments and
distinction of three classes of long-branch effects Johann Wolfgang Waegele, Christoph Mayer BMC Evolutionary Biology 2007, 7 :147 (28 August 2007) [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research article
New insights about host response to smallpox using microarray data Gustavo H Esteves, Ana CQ Simoes, Estevao Souza, Rodrigo A Dias, Raydonal Ospina, Thiago M Venancio BMC Systems Biology 2007, 1 :38 (24 August 2007) [Abstract ] [Provisional PDF ] [PubMed ] [Related articles ]
Research highlights 
